RAF Typhoon FGR4s have operated alongside French warplanes in a joint strike against an subterranean weapons facility in Syria employed by the IS group, according to the UK's MoD.
The location, pinpointed through surveillance, was thought to be housing weapons and explosive materials, the statement said, and was positioned in hills just to the north of Palmyra in central Syria.
"The RAF jets used Paveway IV guided bombs to target a number of access tunnels providing entry to the facility... preliminary assessments indicate the objective was successfully hit," officials stated.
There was no indication of any civilian impact in the strike late on Saturday and each participating jet made a safe return, the ministry further stated.
The British jets were supported by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as ISIS - imposed militant control over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This action shows the UK's leading role, and determination to stand shoulder to shoulder with our allies, to eradicate any resurgence of the terrorist group and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief John Healey stated.
British military aircraft have conducted surveillance missions over Syria to "prevent any attempted comeback" of Islamic State subsequent to its military defeat at the Baghuz confrontation in 2019, the authorities noted.
"I want to thank all the members of the UK armed forces involved in this strike for their skill and their valour," the Defence Secretary said. "They were among a great many UK service members deployed over the festive period. This mission, to eliminate dangerous terrorists who pose a risk to our way of life, shows how our armed forces are always on standby, continuously, protecting the UK domestically and strong abroad."
During December, the United States armed forces executed what it called a "major assault" targeting Islamic State objectives in the country, after an assault killed two American soldiers and a local interpreter in the Palmyra area.
The United Nations says Islamic State still has an estimated 5,000 to 7,000 militants in both countries.
